Anesthesia

One of the oldest forms of medical treatment is described in Genesis 2:18, 21-23, where the Creator Himself “caused a deep sleep” to come upon Adam while He took out the rib, closed up the incision, and made a “help meet for him.” Relief of pain is intimately associated with the rendering of needful medical care. This is one of the physician’s cardinal responsibilities.
For certain patients, some forms of severe pain may be life threatening. However, in the case of most effective pain relieving medications, addiction can occur, with distortion of mental imagery to the point of serious impairment. Thus, it is wise to look for the simplest methods of relieving pain when attempting to perform surgery.
Probably the oldest form of pain relief is refrigeration anesthesia. Extremities can be rendered pain free with ice packs. This is particularly valuable in the case of vascular disease where cardiac and circulatory impairment makes general anesthesia risky. During the World War II, army medics discovered that troops suffering from frostbite might save their limbs if the extremity remained frozen until medical care could be secured. This observation influenced all currently accepted first aid for frostbite used in our country.
In order to properly administer refrigeration anesthesia, the extremity needs to be cooled to the point of numbness, while keeping the remainder of the body warm to avoid a general drop in emperature, chilling, or agitation. Ice packs or snow can be used to progressively cool an xtremity, either a hand or foot. If the surgery is to be localized to the arm or leg, place the pack
just above the site of amputation. This reduces blood loss and allows for a careful, meticulous dissection of the tissue. Broken bones can be set with refrigeration. In the case of a simple fracture of the hand or wrist, immerse the extremity in ice water for one-half hour or more. This will allow manipulation and bone setting to be done quite painlessly.
Refrigeration can also be used topically in the removal of warts, moles, and other skin lesions. Dry ice or liquid nitrogen can be applied with a cotton applicator to freeze a small area and render it numb to pin prick.
A second method of anesthesia is the application of gradual pressure on a nerve. The ulnar nerve at the elbow (funny bone) is quite amenable to pressure. Quite often in certain positions a foot or a hand has been known to “go to sleep” due to stretching or pressure on an affected nerve. nowledge of neuroanatomy can utilize this principle favorably for surgery to an extremity.
Counterirritation can also be applied with electric stimulation near the point of incision. This can utilize DC current, but it is more effective with a pulsed generator, such as rehabilitation centers employ in treatment of chronic pain. Desensitization can be obtained with liniments and ointments, mustard packs or plasters. Even animal surgery has been performed using
counterirritation, e.g., the “twitch” on the nose of horses. Finally, it is helpful to understand some of the common injectable anesthetics that are used locally for the relief of pain. These are used both in dental and surgical care. But they have some side effects and potential allergic reactions. Injectable narcotics should always be avoided, as they leave behind serious effects on the brain. They are not only difficult to metabolize, but because of their tendency to produce euphoria can become rapidly addicting. On rare occasions for major procedures, general anesthesia may be necessary. The gaseous agent used in these cases should be that which is most rapidly metabolized and least toxic to the system. Nitrous oxide and oxygen are commonly employed together to relieve mild pain. Although ether is quite flammable, it still remains the safest form of general anesthesia, due to its rapid clearing from the blood by the way of the lungs and relatively low toxicity to the liver and other organs. Open drop techniques in a well ventilated area can be used, but for safety reasons general anesthesia ideally should be performed in a hospital. Newer anesthetic agents (Halothane, Ethrane, etc.), although more likely to cause toxicity, are less dangerous to the heart and usually nonflammable. Regional blocks, local nerve blocks, and spinal anesthesia have their places in hospital settings but it is beyond the scope of this book to detail their applications.

Suturing

Considerable practice is required to suture incisions and lacerations quickly and accurately. Yet these skills are not beyond the reach of the average layman gifted with manual dexterity or an interest in mastering the art. If possible, practice your suturing techniques on a piece of sponge rubber, upholstery, or even a pillow. Some surgeons become skilled in knot tying, practicing on door handles or in the automobile while traveling. The accompanying diagrams, located on pages 178 to 189, help demonstrate the principles of the three basic methods of surgical knot tying. The one described as an “instrument tie” utilizes a hemostat or needle holder, while the others require only skillful fingers for proper use. I would suggest that a novice begin with the two-handed tie and instrument tie, adding more complex forms as skill is gained.
Avoid tying the sutures so tightly that insufficient blood flow to the skin edges results. This would cause delayed and incomplete healing of the wound.
“Approximate, don’t strangulate” is the watch word for closure of lacerations with sutures. Human bites, animal bites, and lacerations opened longer than 12 hours, or those grossly contaminated are not sutured, but allowed to granulate and heal by secondary intention.
The placement of sutures and selection of suture material will be described in the following sections, as the various types of lacerations and their special care are considered. In a home-like setting it is possible to make the appropriate needles, like bending a sewing needle, sharpening the point in a chisel fashion to better penetrate the skin. Silk or cotton can be boiled along with the needle, thus sterilizing it for use in suturing. Prepared packages, that come already sterile, are available from suture manufacturing companies and can be obtained in various sizes and needle styles. Remember to consult the suture use manual for aid in selecting the appropriate sutures.

Wound Care

There are three basic methods by which a wound heals itself. Primary Intention is the usual type of healing when an incision or laceration is closed immediately to allow close adherence of the opposing skin edges and subcutaneous layers. This permits healing from side to side with the east amount of scarring and pain. The rate of healing of our skin depends on its blood supply and the presence or absence of pressure, tension, and infection. The facial skin, with its rich blood supply, can heal in 3-5 days, while a thickened area of skin with less nutritive potential, such as the back or feet, may require two weeks or more. If sutures are placed, it is important to know how long healing will require to avoid too early removal and wound separation.
Secondary healing of a wound occurs when the laceration is too large to be closed or is infected and must be left open. A general principle of laceration treatment is this. A wound that has been open more than 8-12 hours is never sutured, since infection may already have developed. In uch case, granulation occurs with the formation of a specialized tissue across the wound, and later coverage with new skin. Some deformity and scarring usually occurs. Nevertheless, with the exception of very large ulcers, the skin healing is usually complete. Understandably, this akes longer. Proper care of the wound to prevent or treat infection will serve to hasten the healing process.
The third method involves the initial formation of granulation tissue, then a secondary closure of the wound with sutures. This accelerates the healing in large open lesions and is usually used hen a surgical wound, for some reason, separates and must be closed again. Even more scarring takes place as a rule, but the healing is usually complete.
Some essential factors in wound healing are the presence of adequate protein, vitamins, oxygen, and the prevention of infection. It is generally recognized that the normal rate of healing in a perfectly healthy patient is the optimum rate that can be obtained. Wounds do not heal as well in anemic patients. With a normal complement of white blood cells the healing of a sterile wound is not impaired. However, when infection is present delayed healing does occur. Swelling (edema), whether local or general, appears to interfere with the healing process. Older individuals take onger to heal than the young. Endocrine factors, such as the possible deficiency of thyroid or growth hormone, or adrenal dysfunction, may retard or interfere with the healing process.
Local factors are important. According to Van’t Hoff’s law, reactions occur more rapidly when the temperature is increased. Conversely, hypothermia will delay wound healing in most areas, lthough cold is sometimes used for pain control. The areas of the skin which have the best blood supply, such as the face and neck, normally heal the fastest. Fat persons tend to heal more slowly, and their wounds tend to separate more often than in people of normal weight. Skin utures are usually left in longer. Cleanly incised wounds will heal more rapidly than irregular jagged lacerations. The presence of a blood clot or hematoma may interfere with proper wound healing by preventing close contact of the walls of the wound, and thus there forms a pocket, called “dead space.” Infected fluids, pus, and foreign bodies will all retard the healing of these wounds. It is critical to cleanse the wound of all foreign debris, irrigating it thoroughly before any suturing is attempted. Suture material is also important in the care of wounds. Although stainless steel is the least reactive, it is difficult to handle and remove. The absorption of foreign material, such as gut, silk, cotton, and nylon will occur slowly, in the order that they are here
mentioned. Newer sutures of nylon, Dacron, and Teflon last longer and cause less reaction, but are not suitable everywhere. A suture use manual may be consulted to aid in selecting ppropriate materials. The suture manufacturer’s suggestion of needle size, type, and techniques should also be consulted.

Caries

Tooth decay (dental caries) starts with the destruction of the enamel cap by micro-organisms
present in the oral cavity and adherent to the tooth surface. This leads to exposure of the underlying dentin to the oral environment and to its destruction by bacterial proteolytic enzymes. The dental management is the way of teeth manage. Caries will not occur that somebody have a good dental management.
Enamel caries will not be visible in routinely prepared histologic sections as this tissue dissolves
completely during decalcification. In ground sections made from undecalcified teeth, microscopic
examination under transmitted light will reveal optical alterations related to decreased mineral content of a still-intact crystalline structure.
These alterations tend to occur over a coneshaped area having its base on the surface and its point towards the amelo-dentinal junction. With increasing loss of minerals from the enamel structure, this tissue will disintegrate. The dental consultant can make some suggestion about the caries.
Sometimes, this destroyed enamel will contain so much organic material that it is still present in decalcified sections where it is visible as a basophilic amorphous mass.
The initial carious lesion in dentin afflicts the tubuli that serve as a highway for bacteria to spread into the dentin. As the tubules of the carious dentin become more distended due to breakdown of their walls by the proteolytic enzymes excreted by the invading bacteria, they may fuse and form spindle-shaped cavities perpendicular to the tubules. Fusion of afflicted tubules over a longer distance may also create spindle-shaped cavities in the same direction as the tubuli run. Through the continued loss of dentin between the tubules, its inner structure crumbles away .
When caries is not halted by dental treatment, bacteria and their toxic products will reach the
soft inner part of the tooth, the dental pulp, and evoke an inflammatory response . Subsequently,
the pulp dies and toxic substances from the pulp space diffuse through the apical foramen into
the adjacent periapical part of the periodontal ligament and surrounding jaw bone. Periapical
disease will now ensue. If the root surface of a tooth is exposed due to periodontal disease, the root-covering caries may also be the victim of carious decay. At this site, the bacteria penetrate into the cementum using the collagen fibres that once anchored the tooth in its tooth socket as pathways. The dental consultants can make solution about it.

Antisepsis

One of the outstanding advances that medical science has made in the past hundred years is the establishment of antiseptic principles in the practice of surgery. Milestone discoveries were the germ theory by Pasteur and Koch, the emphasis on hand washing by Semmelweis, and the principles of antisepsis by Lister. To understand the relationship between infective agents and disease has allowed the art and science of surgery to develop many new techniques, as well as life-saving procedures.
Fundamentally, the principles of antisepsis deal not only with the presence or absence of germs, but also with the resistance of the person (host) to their invasion. The acid mantle of the skin and our body’s resident normal flora constitute an important barrier to the growth of disease-producing germs. Enzymatic protection by lysozyme in the nasal secretions, tears, saliva, and other mucous membranes affords a defense of marvelous significance and complexity.
From simple wound care to most complicated surgery, every individual should know how to avoid contamination by harmful germs. During the 19th century in Austria, Doctor Semmelweis began to encourage hand washing, requiring this of his residents after each post-mortem examination and before contact with maternity patients. The death rate from infection dropped
precipitously. Although this brilliant physician was persecuted by his own profession for these “strange” doctrines, decades later he was acclaimed a medical trailblazer. Without doubt, the washing of hands is as important to safe surgery, as the use of water internally is to fighting fever.
It is especially important to know how to wash the hands and prepare them to handle diseased or injured tissues. Usually before surgery, a soft disinfected bristle brush is used to scrub the hands starting first around each finger, the ends and sides of the fingernails, the palm and backside of the hand, the wrist, and then the forearm. To prepare for a delicate operation, ten minutes of this type of scrubbing is required, typically with an antibacterial soap. Sterile rubber or latex gloves should then be worn. Disinfectants such as organic iodine (Betadine), hexachlorophene (Phisohex), or other antibacterial soaps are used to prepare the patient’s skin for the incision. Where this is not available, soap and water are employed, however the scrubbing must be prolonged. It is well to remember, moreover, that the mere washing of the hands with any substance does not guarantee a totally germ-free skin.
Sweating is especially common under rubber or latex gloves, with the natural bacteria present in hair follicles and around the nails. Thus the bacterial count is only transiently suppressed, while our real line of defense is our body’ sresistance. Several routines and techniques of skin preparation will be described in the accompanying table.
In the treatment of skin wounds, copious irrigation with water is essential, With some force, the stream of water is directed at the contaminated areas. The wound is thereby cleansed, allowing germs, foreign debris, and blood clots to be washed away, making the area clean for closure or suturing. Preparation of the skin with appropriate antiseptics is also helpful. Proper nutrition to the injured area includes abundant oxygen and vitamin C to aid wound healing. Elimination of refined sugar assists in fighting infection. These measures, together with the avoidance of tobacco and other harmful substances that impair oxygen supply, will enable healing to occur rapidly.

The Impact of Alcohol : The heart and the circulatory system

Lichtenstein (2003) states that 15 million deaths in the late 1990s could be attributed to cardiovascular disease. The American Heart Association has pointed out that coronary heart disease and the related cardiovascular disease is the number-one killer in the US, accounting for almost one in two deaths among Americans and more deaths than are caused by all the forms of cancer combined. The impact on disability and the attendant economic loss are enormous.
Atherosclerosis (‘hardening of the arteries’) is the term used to describe a number of pathological events occurring in arteries and which are responsible for coronary heart disease, stroke and diseases of the peripheral circulatory system (Fisher 1991). Atheroma (from the Greek ather = porridge) comprises deposits of fatty material on the walls of arteries – a material comprising cholesterol, triglycerides, brous tissue and red blood cells. As it builds it restricts blood ow and if this is in the coronary artery then heart attack and death may follow, as the heart muscle does not receive suf cient oxygen. Atheroma has also been associated with the development of cataracts, macular degeneration in the retina and the development of cancers (Emerit et al. 1991; Tunick et al. 1994). If the atheroma accumulation (plaque) is ruptured a blood clot may form which not only can accelerate the blockage of the artery concerned but also may break loose and plug another artery, increasing the risk of heart attack or, if the newly blocked artery is in the brain, a stroke.
Plainly, the intake of saturated fats and cholesterol increases the risk, although it must be realised that four- fths of the cholesterol is made in our bodies and does not come through the diet. The quantity of cholesterol produced is increased in proportion to the level of saturated fatty acids in the diet (polyunsaturated fatty acids reduce blood cholesterol), and also the trans saturated fatty acids, i.e. those that are produced industrially by catalytic hydrogenation (Krisetherton 1995). High sugar intake can lead to high formation of saturated fats in the body. Indeed, any imbalance in metabolism such that there is an excess of calories over those needed to sustain the body will lead to an accumulation of fat. Obesity, hypertension, diabetes, sedentary living and the use of cigarettes all increase the risk of atherosclerosis.
As cholesterol and other lipids such as the triglycerides are insoluble in aqueous systems, they are transported through the body by combination with proteins, as lipoproteins. The principal carrier of cholesterol is low-density lipoprotein (LDL) and there is a strong positive correlation between its level and the risk of atherosclerosis. Hence LDL is frequently referred to as ‘bad cholesterol’. A lower percentage (20–30%) of the blood cholesterol is in the form of high-density
lipoprotein (HDL), which is responsible for transporting cholesterol away from the arteries to the liver where it is metabolised. This role has caused HDL to be named ‘good cholesterol’, such that high levels of HDL appear to afford protection against heart attack. Thus there is an inverse correlation between levels of HDL and atherosclerosis.

Alcohol : Direct and indirect impacts on body health

There are at least two ways in which an alcoholic beverage such as beer might impact bene cially on the body: rst, through a direct physiological impact on bodily tissues and functions (which will be focused upon here); second, through indirect impact, but founded equally on a physiological interaction. The mellowing in uence that moderate consumption of alcohol has, with its calming and relaxing impact, will of itself have a sparing effect on stress-related illnesses (Morrell 2000). Cleophas (1999) concludes that there is a signi cant psychological component in the bene cial relationship between moderate alcohol consumption and mortality.
In either instance it will be recognised that excessive alcohol consumption will shift the status quo in a negative direction. We will address the incontrovertible direct damage to body organs that can be caused by overconsumption, and there is no denying the antisocial impact of excessive alcohol consumption in terms of behavioural changes and drink driving. One problem emphasised by many writers is the impact of underreporting alcohol consumption.
Dr Thomas Stuttaford (who for years has written a most engaging column in The Times) presents a fascinating experiential account of the likely reasons why his patients in rural Norfolk enjoyed a lesser incidence of cardiovascular problems and tended to live longer than did their counterparts in London (Stuttaford 1997). First, they had enjoyed less sedentary lives, with less dependence on the automobile. Second, they took aspirin daily to counter the osteoarthritis brought on by working in soggy agricultural conditions. Third, they weren’t teetotallers. And their chosen drink was beer, with the occasional celebratory whisky. It is of course not possible to con rm with any certainty that there was a causal link between any of those three factors and Stuttaford’s observations on mortality. Indeed, the reader will recognise the dif culty of pursuing robust research in this entire area, for the simple reason that studies relating health to any type of food intake must inherently try to remove as many interfering factors as possible and this is not easy:

Additional methodological problems are presented by a number of ‘confounding
factors’ such as age, sex, body mass index, diet, physical activity, smoking, coffee
consumption, educational attainment, type A/B behaviour, socio-economic status,
and medical history, that may be factors in particular health problems in persons who have been the subjects of the reported studies. For example, a generally
poor nutritional condition could possibly play a signi cant role in various health
problems associated with heavy drinkers.
Butterworth (1993)

Studies based on individuals’ reporting of their dietary intake are not as controlled as those in which feeding trials are performed with laboratory rats with de ned diets. Yet, of course, what is observed with a rat does not necessarily extrapolate to the human. We must critically evaluate the breadth of evidence that is presented. Most assume that if suf cient evidence of diverse origin is offered then ‘there must be something in it’. Much of the attention that has been paid to the impact of alcohol on the body has been for its negative effect on those who abuse it. These effects are amply described in the Oxford Textbook of Medicine (Weatherall et al. 1996) and, in more prosaic form, by Stuttaford (1997). In the discussions that follow I refer to these impacts and the reader is referred to those texts for more information.

The Impact of Alcohol on Health

The effect alcohol, including in the form of beer, might have on the overall state of healthfulness of the body. What harm might it do and might it actually do some good? And let us start from a baseline statement that alcohol is relatively non-toxic, with an oral LD50 for the rat of 13.7 g/kg (i.e. the amount of ethanol which will kill half of the animals in an experimental population) (Bakalinsky and Penner 2003) Increasingly the evidence is that there appear to be bene ts in drinking beer (and other types of alcoholic beverage). Guallar-Castillon et al. (2001) concluded that the consumption of total alcohol (wine and beer) was associated with a lower prevalence of sub- optimal health. Hospitalisation is less acute for daily moderate drinkers (Longnecker & McMahon 1988), especially for women who had consumed between 29 and 42 alcoholic beverages in the fortnight prior to lling in the questionnaire. Artalejo et al.
(2000) found that moderate drinkers in Spain were less likely than abstainers to use healthcare services. Meanwhile Wiley and Camacho (1980) showed that moderate alcohol consumption (17–45 drinks per month) was associated with the most favourable adjusted health scores.
Beer drinkers were shown by Richman and Warren (1985) to have signi cantly lower rates of morbidity (sickness) than expected – one drink per day giving 15% less disability than was the case for the general population. There will be those reading this who will not be able to countenance such ndings.
If these people nd it hard to swallow that drinkers, imbibing in moderation, could be less ill, then they might note that they have certainly not been shown to be more sick. However, we must stress always that many of these studies are dealing with correlation, not necessarily causality. Some will argue that there may be other confounding factors not explored in the studies, and that those who tend to drink in moderation may have other lifestyle attributes that are the true reason for their enhanced healthiness. However, the sheer frequency of studies that have demonstrated the bene ts of restricted alcohol intake, weigh heavily in support of the merits of sensible drinking.
In the mid-1990s, the Department of Health within the British government addressed the matter of recommended safe limits for drinking. After (we presume) careful consideration of the scienti c and medical evidence available up to that stage, they increased the recommended limit for men from 21 units to 28 units per week, with the advice to
women being to drink no more than 21 units per week (previously it had been 14). They stressed that the daily maximum should be 4 units and that binge drinking (the equivalent of taking all of the weekly allocation at one sitting) is absolutely undesirable.
Individuals differ substantially in their bodily response to alcohol. Various factors will play a role, including body weight, general state of health, amount of activity, and whether the alcohol is being consumed on its own or alongside food. The UK guidelines are precisely that: blueprints to give some guidance to people to judge sensibly what is and what is not an advisable amount of alcohol to consume. They are not recommendations to drink: they are certainly not instructions. Rather they are a common-sense judgement on what is likely to be healthful for a sensible and healthy adult. And the fact that the levels were increased is testimony to the burgeoning evidence that there is real merit in moderate consumption of alcohol.
The author of a newspaper article in California once highlighted the number of times I had invoked the word ‘moderation’ when she interviewed me. I make no apology for using the word again here (particularly as a glance at the thesaurus in my computer offers the word temperance as a suggested alternative!). As the reader should surmise from what follows, there is more than ample evidence for the harmful effects of sustained, heavy intake of alcohol in all its forms. However, it will be noted that the serious ailments are primarily associated with extreme alcoholism, and a consequence of vastly more alcohol ingestion than is the norm for the great majority of adults.

Beer: a vice or a staple part of the diet?

Were we able to transport ourselves back to the Middle Ages and enquire in England, Flanders, Bavaria or Bohemia about the key features of the popular diet, ale or beer would unquestioningly and unhesitatingly be listed alongside meat, bread, milk and vegetables. The questioner would be regarded as being mightily peculiar if he or she were to question ale’s legitimate place on the table. It was neither a comfort food nor an extravagance. It was an integral part of the food intake in all walks of society. In eighth-century England a monk might consume eight pints of ale a day. Beer in Britain has long been considered to be a key part of the diet, as much so as wine in France. Henry Brougham MP (Brougham 1830) said that ‘To the poor the beer is next to a necessity of life.’
Over 50 years ago the nutritive value of beer was emphasised. An admittedly weakish beer [3% alcohol by volume (ABV) in the austere early post-war years] was claimed to provide 200 calories and a fth of a working man’s requirement for calcium, phosphorus,nicotinic acid and ribo avin (Bunker 1947). The satisfaction of having at least part of one’s dietary intake in a pleasurable form was not sneered at then.
Perhaps the rst person to conduct a serious study of the impact of abstinence, moderation and excessive drinking on health was statistician Raymond Pearl. On the basis of interviews with over 2000 workers in Baltimore, he concluded almost 80 years ago that on average moderate drinkers lived longer than abstainers and much longer than those who were heavy drinkers (Pearl 1926).
Yet now, at the dawn of the twenty- rst century, beer-drinking is regarded in many societies as a vice. It is surely astonishing that in the United States it is possible to buy cigarettes at the age of 18, but it is not legal to purchase alcohol until the age of 21. It would be a struggle to identify any merit associated with smoking, with the possible exception of its role as an anxiety relaxant. By contrast there is accumulating evidence that alcohol, including beer, in moderation can have a bene cial impact on health and wellbeing.
In passing, let us consider the legal age at which, in the US, it is possible to partake of other activities that surely might be considered a genuine risk to health and wellbeing, not only for the partaker but also for those around them. A child may legally drive a car, with relatively few restrictions, at the age of 16. More alarmingly, 35 states in the US have no licensing or registration requirements for guns (www.soros.org/crime/ higlights.htm). Seven states lack a legal minimum age for buying a ri e or shotgun from an unlicensed dealer, while six states have no legal minimum age for a child to possess a handgun. In ve states there is a minimum age – 16 in New York, Georgia, Vermont and Alaska, and just 14 in Montana. But the minimum legal age for drinking alcohol in all 50 states is 21!
Opinions about the relative merits and de-merits of smoking, driving, guns and alcohol will of course differ between individuals. Certainly if we consider the respective virtues of smoking, weapon use and alcohol (in restraint), then it seems to this author that there may be a warped set of priorities in one country at least. Nonetheless beer is the second most popular drink in the United States, with annual average per capita consumption at 357 8-ounce servings, after sodas and other soft drinks (861) (Beverage Digest 1998). Worldwide production of beer in 1999 ran at 0.13 billion litres.

Several drugs and hormones have an effect on body weight.

Some hormones cause weight gain and others cause weight loss. Hormones that cause weight gain are of particular interest, because if researchers can study and understand how they work, they may be able to develop drugs that can interact with these hormones in a way that makes it easier for people to lose weight. Insulin is a hormone that helps turn glucose (the sugar found in food) into energy the body can use. High levels of insulin lead to weight gain, although the reason why is not fully understood. Drugs used to treat diabetes, such as insulin and medications that make the body produce more insulin, cause weight gain. Obese people often have higher levels of naturally occurring insulin than their leaner counterparts.
Female hormones, like progesterone and estrogen, are associated with weight gain. Obese women most commonly begin to gain weight after puberty, when their bodies begin to produce these hormones. Birth control pills contain estrogen and progesterone, and are associated with weight gain. Today, birth control pills cause less weight gain than in previous years because they contain lower levels of estrogen. Some women may gain more weight than usual during pregnancy, up to 110 pounds (50 kg), which may be related to differences in their hormone levels during pregnancy, as compared to other pregnant women. Women who gain excessive weight during pregnancy may never fully lose this weight. Changes in hormone levels also occur during menopause. These hormone changes lead to a change in fat distribution, including increased central obesity (fat around the midsection or waist). This fat distribution is associated with increased health risks, especially heart disease.
Thyroid hormones increase metabolism and cause weight loss. People with the disease hypothyroidism (underactivity of the thyroid gland) have a smaller amount of thyroid hormone. People with hypothyroidism are predisposed to weight gain.When these individuals are treated with a drug that contains thyroid hormones, they lose weight. Thyroid hormones are dangerous in very high levels and must be monitored closely when taken. An excess of thyroid hormones in the blood can lead to several health problems, including high blood pressure, nervousness, insomnia (trouble sleeping), menstrual cycle changes, heart palpitations (the feeling that the heart is pounding), and fever. Several hormones that may play a role in weight gain have recently been discovered. One of these is leptin, a newly discovered hormone produced in fatty tissue. Increased leptin decreases food intake and increases metabolism in rats and, according to some early studies, in humans as well. Other hormones released by the stomach—including neuropeptide Y, cholecystokinin (CCK), enterostatin, and polypeptide Y 3-36— tell the body it has consumed enough food and should stop eating. Another hormone, ghrelin, is produced by the
stomach. Ghrelin signals hunger and increases appetite.
Ghrelin concentrations increase in response to weight loss. This may make ghrelin partly responsible for people gaining weight back after a successful diet. Table 2.2 lists some of the hormones that influence body weight. Clearly, many hormones affect body weight. Some of these hormones are known, and some have not yet been discovered. By studying these hormones researchers can better understand what causes people to gain and lose weight. Eventually, researchers may be able to develop drugs that can change levels of these hormones in the body, thus giving people who are overweight or obese another weapon in the weight loss battle. Intensive study is required to identify the possible negative effects of increasing or decreasing the level of hormones in the body.

Developing a Good Relationship with Your Doctor

In the past, many people saw the same doctor for years—sometimes for most of their lives. Today, people are much more mobile, making a long-standing patient-doctor relationship more difficult. People move to new locations, accept new jobs, and change healthcare coverage. Any of these situations may require a change of doctors. Some health plans restrict your choice of doctors to those who participate in their plans. Seeing a specialist may entail getting a referral from your primary care doctor. Choosing a new doctor takes more than just a word-of-mouth recommendation from a friend. You need to think carefully about what you are looking for when changing doctors. The area of medicine in which a doctor specializes is an important consideration. If you have a particular medical problem, such as heart disease, you will probably want to see a cardiologist (a doctor who specializes in diseases of the heart). If you are generally healthy, an internist (a doctor who specializes in the care of adults) or a family physician is probably the best choice. You may also prefer a male doctor over a female doctor. Some people choose medical assistant which he or she admits patients. The location of the doctor’s office also is a factor. It should be easy to reach from your home or workplace, especially if you rely on public transportation.
Once you have narrowed your choices, find out more about the medical assistant school you are considering. Important information includes where they trained, how long they have been practicing, and their specialty area and whether they have been certified by the board in that specialty.
medical assistant schools needs to communicate well with you by fully answering all of your questions and explaining medical terms and procedures in language you can understand. they also needs to treat you with respect and keep waiting times to a minimum. If you feel that you are not getting all the information you need to follow medical assistant instructions or that your appointment times are too rushed to address all of your medical concerns, Keeping an established relationshipis much easier and more valuable than starting all over again.

WHEN ARE DIET PILLS, ERECTION, HAIR GROW DRUG RECOMMENDED?

DIET PILSS NEED?
Overall, in carefully selected patients, a doctor may prescribe appropriate drugs to be used in conjunction with diet and exercise to achieve weight loss. The only drugs recommended for use by the National Heart, Lung, and Blood Institute (NHLBI) are those that have been approved by the U.S. Food and Drug Administration (FDA). FDA-approved drugs have been studied and determined to be safe and effective for some, but not all, people.
According to the NHLBI, people who are appropriate candidates and should consider taking diet pills are adults with a BMI of greater than 30 kg/m2 or those with a BMI of higher than 27 kg/m2 who have health problems related to being overweight. Diet pills, like any other medication, have risks associated with their use. Therefore, diet pills should only be used by people who are at high risk of developing weight-related health problems. For people who are obese or overweight, the benefits of weight loss are generally greater than the risks associated with taking slimming pills. Several slimming pills have been studied for use in children; however, doctors only recommend using them in extreme situations.
The National Institutes of Health (NIH) has established guidelines on the use of diet pills. These guidelines are used by health-care practitioners both within and outside the United States. The information contained in these guidelines helps to determine who should and should not use weight loss medications. This is important because people who use diet pills inappropriately risk potentially devastating effects on their health.
ERECTION DRUGS NEED?When a man is aroused, nerve signals are sent from the brain and around the penis. These nerve signals cause chemicals to be released that relax the muscles in the penis. Normally, these muscles are constricted so that blood cannot flow into the penis. When these muscles relax, large amounts of blood are able to enter the penis, causing an erection. An erection is reversed when another chemical (known as phosphodiesterase type 5 [PDE5]) breaks down the chemicals that caused the muscles to relax in the first place. This causes the muscles in the penis to constrict again as blood leaves the penis. Cialis works by blocking PDE5. When PDE5 is blocked, more of the chemicals responsible for the erection remain, so the muscles in the penis do not constrict. This allows blood to stay in the penis longer, which allows the man to maintain an erection.
HAIR GROW DRUGS NEED?With at least forty treatments for baldness patented in 1996 and $200 million budgeted for clinical trials in 1997, you'd think someone might have figured out by now why men lose hair. But the lab guys know only one big thing: Hair follicles shrink and die. They've proved that this tragedy is triggered by the body's especially potent testosterone derivative, DHT. But researchers can still only theorize about why the perfectly normal presence of DHT leaves some otherwise healthy men mourning their hair as it swirls down the drain.
Propecia, the next treatment to grind its way through the FDA-approval machinery, probably within the year, will be Merck's promising finasteride tablet, Propecia. Finasteride inhibits the enzyme that turns testosterone into DHT--the first domino in the chain reaction that ends in follicle death. It first appeared in the guise of Proscar, a drug that combats prostate enlargement, another problem caused by DHT. Merck's trial results have raised high hopes for Propecia's effectiveness: More than half of those treated had "clinically significant increases in growth of new hair." Some baldsters, wanting to get the jump on the approval process, are already cadging prescriptions for Proscar from their physicians.

HEAT AND DRUG STABILITY

The variety of different body matrices that can be analyzed to determine the presence or absence of different psychoactive substances is extensive, ranging from semen to cerumen. There are, however, practical limitations to the extent to which different biological samples can be used, and the mechanism of collection and supervision of samples are critical to the procedure. This focuses on those biological samples that are commonly used for testing within various drug treatment settings, namely, urine, saliva, blood, and hair. Urinalysis is routinely used in hospitalbased services, blood in forensic environments, hair analysis for medicolegal cases, and saliva tests have been used in the prison services and outreach units. Many would advocate that the assessment of psychoactive drug use could reliably be achieved using self-report from the drug user (client). However,the drug rehabilitation are issues around the method of inquiry the context, purpose, interviewer characteristics, etc. that may bias self-report. Circumstances where the drug user sees the self-report to the inquirer about drug use as influential on his own continued treatment or possible loss of privileges are particular examples.
With a focus on alcohol rehab, Allan has recommended that patients presenting with anxiety and alcohol dependence should first be detoxified and reassessed after 6 weeks when only an expected 10% will be found to have persistent symptoms amounting to an anxiety state. The persistent anxiety can then be treated using conventional pharmacological or behavioral methods. She points out that patients may resist such an approach, preferring to deal with their psychological distress before tackling their substance use. People who are dependent on alcohol or other drugs usually succumb to a number of financial, family, health, and relationship problems, and it is not surprising that many will complain of depression; again it is not surprising that 80% or more will recover within a few weeks of abstinence without recourse to antidepressant treatment.

The drug being tested for and the period of time that the clinician wishes to consider influence
the choice of body fluid. Blood and, to a lesser degree, saliva are likely to give the most accurate
measurement of drugs currently active in the system, whereas urine provides a somewhat broader time period, but with less quantitative accuracy. Hair provides a substantially longer time frame. The routine drug testing strategy most widely adopted is to send urine samples to a laboratory for an initial screen to detect psychoactive drugs of interest. Analysis is performed using a semiautomated commercially available immunoassay or thin layer chromatography (TOXILAB) test. Several types of the former test exist and include radioimmunoassay, RIA:Europ/DPC, enzymemediated immunoassay test, Syva:EMIT, and fluorescence polarization immunoassay, FPIA. Recently, several rapid detection devices (near patient test, NPT) for drugs of abuse screening have been marketed in the U.K. Such tests offer a more rapid turnaround of results to aid clinical decision making.
However, all initial drug screen tests are nonspecific and identify only in a nonquantitative fashion the class of drug present, e.g., opiates, amphetamines, or benzodiazepines, etc. Ideally, any positive test result should then be confirmed by a second test working on different physicochemical principles to the screening test. Gas and liquid chromatography with mass spectrometric detection are regarded as the “gold standard” and are favored where legally defensible results are required. It cannot be overemphasized that the confirmation of drug screening test results is essential. For amphetamine-specific immunoassays, the confirmation test provides the opportunity to differentiate legitimate medicines. For instance, pseudoephedrine and phentermine give a positive test result (cross-react) with tests for illicit drugs like amphetamine and methylenedioxymethamphetamine, MDMA. For opiate drugs, initial immunoassay tests for morphine crossreact with codeine, dihydrocodeine, pholcodeine, 6-monoactetylmorphine (6-MAM), morphine glucuronide, and morphine-6-glucuronide. Consequently, if more than one of these substances is present in a urine sample, the test result will relate to the concentration of the sum of all these opiates and their metabolites. In this way an inaccurate picture of the window-of-detection of opiate drugs in urine may be concluded. The clinical benefit of the confirmation test is that it is able to verify the specific substance(s) present. For example, a confirmation test can detect the presence of 6-MAM, the only specific indicator (metabolite) of heroin use .

Management of Drug Abuse

The management of complications from drug abuse demands a variety of skills from airway management to control of seizures and shock. Several reviews have addressed the issues of general resuscitation and toxidromes.
The purpose of Drug rehab is to present a series of management strategies for the emergency physician or other clinical personnel caring for patients with acute complications from drug abuse. Immediate interventions (e.g., resuscitation and stabilization), secondary interventions (e.g., emergency care after the patient is stable), as well as diagnostic workup (e.g., laboratory data, imaging), and disposition of the patient are discussed. This is proposes a variety of treatment approaches based on a review of the pertinent literature and clinical experience. A general treatment approach based on symptom complex (i.e., seizures, coma, hyperthermia) is presented since initial management decisions frequently have to be made without the benefit of a reliable history. This is followed by a brief review of the each particular drug of abuse (i.e., psychostimulants, opiates, hallucinogens).
It should be emphasized that the adverse reaction to a drug may depend on the unique characteristics of an individual (i.e., presence of cardiovascular disease) as well as the type of drug abused. These protocols serve as guidelines only and an individualized approach to management should be made whenever possible. In the setting of drug overdose, coma usually reflects global depression of the brain’s cerebral cortex. This can be a direct effect of the drug on specific neurotransmitters or receptors or an indirect process such as trauma or asphyxia. Treatment deals largely with maintaining a functional airway, the administration of potential antidotes, and evaluation for underlying medical conditions. The following section describes the Drug rehab thats appropriate use of antidotes and the approach to the patient with a decreased level of consciousness from drug abuse.
Level vs. content of consciousness: It is often useful to distinguish between the level and the content of consciousness. Alertness and wakefulness refer to the level of consciousness; awareness is a reflection of the content of consciousness. In referring to coma, stupor, and lethargy here we address the level of consciousness as it applies to the drug-abusing patient along a clinical spectrum with deep coma on one end, stupor in the middle, and lethargy representing a mildly decreased level of consciousness. Agitation, delirium, and psychosis are addressed in a subsequent section with a greater focus on content of consciousness, i.e., presence or absence of hallucinations, paranoia, severe depression, etc. Attributes of a good antidote The ideal antidote should be safe, effective, rapidly acting, and easy to administer. It should also have low abuse potential, and act as long as the intoxicating drug.
The following standard antidotes are of potentially great benefit and little harm in all patients. Thiamine: Thiamine is an important cofactor for several metabolic enzymes that are vital for the metabolism of carbohydrates and for the proper function of the pentose–phosphate pathway.When thiamine is absent or deficient, Wernicke’s encephalopathy, classically described as a triad of oculomotor abnormalities, ataxia, and global confusion, may result. Although Wernicke’s is rare, empiric treatment for this disease is safe, inexpensive (wholesale price of 100 mg of thiamine is approximately $1), and cost-effective.

Nimodipine: Cocaine is known to decrease reuptake of serotonin, which is believed to play a
role in cocaine-induced headaches and may be associated with cocaine-induced vasoconstriction.
Rothrock et al. reported on three cases of amphetamine-related stroke: in one case a 35-year-old abuser had 20 episodes of transient right hemiparesis occurring within minutes of inhaling methamphetamine; later he developed permanent right hemiparesis. In animal studies,
intravenous methamphetamine administration has resulted in narrowing of the middle cerebral
artery branches within 19 min.While the pharmacologic approaches to cerebral vasospasm are varied, the calcium-channel blocker nimodipine has been used widely with proven efficacy in preventing vasospasm associated with hemorrhagic stroke.No studies looking at this issue in the setting of drug-induced hemorrhagic stroke exist. Although two animal studies found that nimodipine potentiated the toxicity of cocaine and amphetamines in rats, it is felt that in selected
patients the risk–benefit ratio may favor nimodipine administration. Such populations may include the drug-abusing patient who is experiencing transient ischemic attacks closely temporally related to substance abuse or who has had a documented subarachnoid hemorrhage associated with cerebral vasospasm. Recent reports suggest no benefit of nifedipine in ischemic strokes of any type.

How to Save Money on Drugs (2)

Shop Around for the Best Price
The same kind of comparison shopping you might do for a car or a coffeemaker can pay off for drugs.
• Buy by mail. If your prescription drugs are covered by insurance, see if the insurer has a mail-order pharmacy. Some offer lower co-payments.
• Call around. You’ll find that drug prices vary from store to store. Try independent pharmacies, national chains, and megastores such as Wal-Mart and Costco.
• Go online. You can find bargains or quickly compare drug prices on the Internet. (If you don’t have a computer, the ones at your public library are free to use, and many librarians will help you find information.) Many brick-andmortar pharmacies have websites that offer discounts on prescription drugs. So do “virtual” pharmacies, which do all their business online. For the most part, shopping for prescription drugs online is safe. One way to tell if the site is legitimate is the VIPPS (Verified Internet Pharmacy Practice Sites) seal of approval from the National Association of Boards of Pharmacy. You can also check with the board to see if an online pharmacy is licensed and in good standing.

Join a Group
Some organizations offer savings on prescription drugs as a perk. If you’re a member of AARP, for example, you can join its MembeRx Choice plan for $20 a year. It offers savings on topselling
drugs. If you served in the military, you may be eligible for the TRICARE Pharmacy or Senior Pharmacy programs. Buying groups such as the Peoples Prescription Plan and the United States
Pharmaceutical Group also offer savings and are open to everyone. (Find more information in the Resources.)

Look for Low-Income Options
Some money-saving options are aimed at low- to middle-income seniors without any drug insurance. The Together Rx Card, for example, provides savings on more than 150 widely prescribed medicines. Some states provide assistance with prescription drugs to low-income seniors or people with disabilities who do notqualify for Medicaid. To quickly find out if your state has such a benefit or if you qualify for other programs, try the National Council on the Aging’s BenefitsCheckUp Web site. (For more information, see the Resources.)

Reduce Your Need for Drugs
If you’re serious about cutting your drug bill, get serious about adopting a healthier lifestyle, which may cut the need for medication. Don’t stop taking your pills first and then try to make lifestyle changes. Make the changes first. When you start getting results, then talk with your doctor about medication changes.

How to Save Money on Drugs (1)

You don’t need the newscasters to tell you that prescription drug prices are on the rise or that insurers are covering less of the cost. For some people, the out-of-pocket outlay for prescription drugs extracts little more than a quiet moan at the cash register. For others, it means skipping medicine or meals in order to pay. Here are some tips for cutting costs.
Get Your Doctor’s Help
Unless a doctor knows you’re trying to cut corners, he or she won’t take price into consideration when filling out the prescription pad. But most doctors are willing and able to help once you mention your concern. Here are a few things to ask about:
• Generic drugs. Buying generic drugs instead of the more expensive brand-name versions is one of the most effective ways to cut your monthly drug bill. For example, a month’s supply of the 20 mg dose of the brand-name statin Mevacor costs about $70, while the same amount of generic lovastatin costs about $35. There’s no need to worry that a cheaper price means less quality. The Food and Drug Administration (FDA) regulates the production of generics just as carefully as brand-name drugs. The only difference may be in the inactive ingredients—things like fillers, coatings, and flavorings. Some doctors worry that the inactive ingredients change how much of the active ingredients the body absorbs. The FDA doesn’t share this concern, though. Some classes of drugs are so new that generic forms aren’t yet available. If your doctor prescribes one of these, ask if there’s a slightly older type of drug that does much the same thing.
• Cheaper brand-name drugs. Sometimes you can trade off convenience for savings. For instance, if your doctor suggests a brand-name combination drug, ask if you can save money by taking the component drugs one by one. In other cases, you can save by taking an older drug two or three times a day instead of using a newer (and more expensive) once-a-day formulation.
• Starting small. When you start a new drug, ask your doctor to give you a prescription for just a week or two. This way you can see if the dosage is right and if the drug agrees with you. If everything goes well, then you can fill a longer-term prescription. If it doesn’t, you aren’t stuck
with a stockpile of pills you paid for but can’t use.
• Starting low. Ask about starting a drug at the lowest possible dose, especially for a drug that’s relatively new.
• Splitting the difference. You expect to pay about twice as much for a two-pound box of pasta as you do for a onepound box. But the same pricing concept doesn’t always apply to drugs. Often, you can save money by asking your doctor to prescribe pills in twice the dosage you need.
Then you can cut them in half to double the number of doses. This approach is not for everyone, and it can’t be done for all drugs. Capsules and timed-release formulas, in particular, should never be split.

Low HDL

Recommendations for people with low HDL levels are a little less cut-and-dried than those for the other lipid problems. That’s because we don’t have any studies showing specifically that if we raise HDL levels, heart disease risk goes down. We know HDL is good for the heart, so we believe that the higher the levels the better, but no studies have unequivocally proved that. Why? Because all the drugs we employ to raise HDL levels typically lower the LDL or triglyceride values at the same time. This makes it hard to tell which change caused the benefit of fewer heart problems. Recent animal studies have also shown that there may be good ways to raise an HDL cholesterol level and bad ways to do that, so without knowing how a drug has led to a change in HDL, one can’t readily predict if its effects would be beneficial or detrimental.
None of the statins alter HDL levels very dramatically (about 4 percent to 10 percent increase), whereas the fibrates and niacin do a better job of raising HDL levels (about 10 percent to 15 percent). Despite the unanswered questions about treating HDL, it is a very important blood value, with some studies indicating it predicts coronary disease risk better than any other single lipid value. The large observational study called the Framingham Heart Study suggests that every 1 mg/dL decrease in HDL increased the risk of having a heart attack by 2 percent to 3 percent. And the NCEP classifies an HDL level below 40 as a major risk factor for developing heart disease.
Most doctors don’t often prescribe medications to raise HDL levels, because the drug that works best—niacin—can be hard to take and may have side effects that are particularly undesirable in
the population most likely to have low HDL levels: diabetics. More options should become available in the near future, as the study of HDL metabolism is the most active area of cutting-edge research in the lipid field, and several new approaches are currently in early clinical trials. Luckily, though, there are a lot of lifestyle changes that raise HDL levels that are also beneficial to the rest of your cholesterol profile, your heart in general, and just about every other part of your body. The following can help you raise your HDL level:
• Exercising
• Not smoking
• Avoiding foods with trans fats (a lot of margarines, fried foods, some commercial baked goods)
• Losing weight if you’re overweight
• Drinking a small amount of alcohol every day (typically one drink for women, two for men)
Again, while we don’t know if raising HDL through these changes will help prevent heart disease, we do know that their other benefits will definitely decrease heart disease risk.

How Not to Get Sick : Primary Prevention

Prevention is better than cure—and less expensive than cure. So if we are going to discuss how to save on the cost of healthcare, we might as well start with the least expensive method: how to keep from getting sick in the first place. We can prevent a lot of diseases by living a healthy lifestyle.
The very essence of healthy living is simply to do the things that are good for our bodies and avoid the things that are bad for our bodies; it is that simple. However, since there are many things that are good for our bodies and many things that are not, let’s list the main ones:
Things that are good for our bodies
• Regular exercise
• Proper nutrition
• Routine physical examination
Things that are bad for our bodies
• Smoking
• Excessive alcohol intake
• Illicit drug use
• Unprotected sex with multiple partners
Unfortunately, there are a number of reasons why many do not live healthy lifestyles or can’t seem to do it on a continuous basis. The main excuses are:
1. It is not a priority.
2. They can’t seem to find the time to do it.
3. It can be complicated and they just don’t know what to do.
4. It is expensive.
The biggest stumbling block is that, for most of us, living a healthy lifestyle will cause us to change the way we live right now in some fashion. And change is hard. The good news is that we can change, and we do it all the time. If we understand how change happens, and then apply that to create a healthy lifestyle, we will achieve our goal.
Change begins as a result of a different mindset. Here are some of the reasons that people who successfully live healthy lifestyles use to keep themselves on the right track:
• I want to look good.
• I need to feel energized.
• I want to stay alive long enough to see my grandchildren.
• I hate going to the doctor or hospital.
• I don’t like spending money on healthcare.
• My mom or dad or relative died from that disease and I don’t want that to happen to me.
• I need to release stress.
• My doctor told me to.
Unfortunately, sometimes a reason is forced on us because something catastrophic happened. For example, it’s often the case that when somebody has a heart attack, that person suddenly starts an exercise program, or when somebody has diabetes he or she starts thinking about diet and losing weight. Don’t wait. It will cost you a lot, both financially and emotionally.
If you achieve the mindset that convinces you to live a healthy lifestyle, you would have taken care of excuses numbers 1 and 2 (not a priority and can’t find time). You will make your healthy lifestyle a priority. Once you make anything a priority, you suddenly find that you
can make time to do it.

Dealing with Hospital Costs If You Do Not Have Health Insurance

If you do not have insurance, do everything you can to stay away from the hospital. In an emergency you may not have a choice, but if it is an urgent or elective procedure, investigate the possibility of using an urgicenter or surgicenter before using the hospital. If you have to use a hospital, look at government hospitals first, then community hospitals, then university hospitals, and specialty hospitals last. If you end up in a hospital, remember that no hospital can turn you away for treatment especially if it is an emergency. Keep the following in mind in dealing with hospital costs if you do not have insurance:

• The first thing to do if you need hospitalization, especially for an elective procedure where you can plan ahead, is to determine if you qualify for any insurance program. Are you poor enough to qualify for Medicaid? Are there any government programs that can give you
  assistance? Call your state health office to find out. Do you belong to a group through which you can get some form of health coverage? Do these things before you get into the hospital because if you do them after, even if you get the insurance, it might not cover a cost that was incurred prior to your getting the coverage.
• Always get a second or third opinion about any procedure. Many treatments have alternatives and sometimes you might not even need the procedure at all. Be sure, however, that you do not stay away from a treatment because of the cost, but rather because another well-respected professional determined that it is not necessary.
• Check out government-run clinics and hospitals. These establishments are not only less expensive but will charge you based on your income, that is, on a sliding scale, and will work out payment plans that you can live with.
• The government subsidizes most hospitals, especially teaching hospitals, because they are expected to take care of individuals who cannot pay for what the hospital charges. In these cases, the hospital will charge you on a sliding scale based on income and you can negotiate a payment plan.
• If you have a complicated or rare disease, one that in all likelihood is very expensive to treat, look into participating in clinical trials. In clinical trials, all your expenses will be paid for including, in some cases, your transportation. Be sure you understand what will be
  done and realize that if it is what is known as a double-blind trial, you might not be getting the active treatment but might be getting a fake treatment or placebo and neither you nor your doctor will know until the end. Not all studies are double blind, however. Some are known as open trials, where you and your doctor know exactly what you are getting.
• Avoid unnecessary services like private rooms and special meals if you can.
• If you need medication that can be brought in from the outside, like Tylenol or even some prescription drugs, it might be cheaper to get them from an outside pharmacy than from the hospital pharmacy. Discuss this with your doctor and let the nurses help you with the
  medication regimens.
• Discuss any consultations with other doctors ahead of time and be sure they are absolutely needed so you don’t end up with more physician charges than are necessary. When you get the bill, go over it with a fine-tooth comb. Very few patients do and there have been stories of hospitals charging exorbitant amounts sometimes for services that were not even rendered. You should realize that all bills are negotiable. Start by getting a sense of
  what the hospital charges the government for that service. You can get that information from the AHD web site (www.ahd.com). Then negotiate from there. When you have reached a satisfactory amount, you can work out a payment plan with the hospital that you can live with.

Individuals in Search of Health Insurance

If you do not have health coverage, either through the government or through a private employer, you are left to find one for yourself. It is a daunting task, one that has left more than 40 million Americans with no health insurance coverage. If this is the case for you and you are seeking health insurance, you may be faced with a number of challenges:

• Insurance companies are reluctant to insure most people with preexisting medical conditions. If they do offer coverage, the premiums are extremely high.
• Many benefits such as maternity care, mental health, and prescription drugs are usually excluded.
• The application process can be long and very intrusive.

Some states have created laws to help control these practices. They include:

• Preventing insurance companies from eliminating coverage for preexisting medical conditions. These laws do not, however, force the insurance companies to accept an applicant, only that if the applicant is accepted then their preexisting condition must be covered. Insurance companies are then free not to accept an individual with a preexisting condition, or to accept one and charge much higher premiums.
• Creating high-risk pools to provide coverage for individuals who have been turned down because of their conditions. These policies are usually more expensive but do provide coverage that would otherwise not be available. An individual with
AIDS, for example, would have a hard time getting regular insurance. A high-risk pool insurance would provide coverage for that individual.
• Creating laws that require health insurance companies to provide health insurance at premiums that are set on a market by market basis. This means that the state is broken up into different markets, and for each market the company creates a rate without regard to age, sex, or health status. Every individual in that market gets the same rate and benefits. For healthier individuals, these programs tend to be more expensive than regular plans.

If you are looking to buy health insurance, contact your state’s department of insurance. Any company that sells health insurance in a state has to be licensed in that state and must comply with the insurance laws of that state regarding what it can and cannot do. Appendix A lists the phone numbers of the insurance departments of the different states.